For a long time (I'm going to say 1950's -1960's), it was pretty fashionable to use photographs in print ads, but to "plus them up" with some airbrushing - either lightly or rather heavily. In this ad from Kelvinator we see a strange array of airbrushing, from mostly-photo-with-light-airbrushing, to completely cartoony.
Wilma Flintstone a cartoon of a woman completely made up. She could have been drawn by Hanna-Barbera. When I look at her, I imagine her being voiced by June Foray.